{"id":3406,"date":"2009-12-23T15:31:47","date_gmt":"2009-12-23T13:31:47","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=3406"},"modified":"2009-12-23T16:08:08","modified_gmt":"2009-12-23T14:08:08","slug":"on-the-tasseography-of-lung-function-genes","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2009\/12\/on-the-tasseography-of-lung-function-genes\/","title":{"rendered":"On the tasseography of lung function genes"},"content":{"rendered":"

Having done lung function testing on hundreds, even thousands of children, I believe that this is not an easy task – it’s not only about abdominal mechanics and airway diameter but also about physical fitness – and let’s be cruel – also about intelligence. Even worse, I remember a long discussion how to adjust lung function parameter appropriately – should we use standing or sitting height? Two new papers large ignore these questions. But read first what the Charge<\/a> consortium writes<\/p>\n

\nIn meta-analyses of GWAS results in 20,890 CHARGE participants of European ancestry, we identified genome-wide significant associations with FEV1\/FVC for SNPs in seven previously unrecognized independent loci (GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and with FEV1 for one previously unrecognized independent locus annotated by at least three genes (INTS12-GSTCD-NPNT). The SpiroMeta consortium independently reported genome-wide significant associations of GSTCD, HTR4, AGER, TNS1 and THSD4 with FEV1\/FVC and FEV1). Both consortia confirm previous GWAS findings implicating the HHIP region for FEV1\/FVC.\n<\/p><\/blockquote>\n

Spirometa has the companion paper<\/a>:<\/p>\n

\nWe … identified associations with FEV1 or FEV1\/FVC and common variants at five additional loci: 2q35 in TNS1 (…), 4q24 in GSTCD (…), 5q33 in HTR4 (…), 6p21 in AGER (…) and 15q23 in THSD4 (…).\n<\/p><\/blockquote>\n

It looks from table 2 (Charge) that only HHIP and AGER can be replicated (and maybe also the vague INTS12 – GTSCD – NPNT region). HHIP unfortunately seems to be a height associated gene<\/a> that probably reveals the residual height influence in the analysis. The AGER gene could point towards some fibrotic processes<\/a> but remains largely in the dark without any functional data. Pretty clear: no asthma genes here, no COPD genes here and severe doubts about a third lung function paper in the NEJM<\/a> tagging MMP12. Anyway, the intelligence gene<\/a> did not show up, nay, nay. One of my fellow bloggers is not talking about tasseography but Rorschach<\/a> test, see what you want to see.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 13.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Having done lung function testing on hundreds, even thousands of children, I believe that this is not an easy task – it’s not only about abdominal mechanics and airway diameter but also about physical fitness – and let’s be cruel – also about intelligence. Even worse, I remember a long discussion how to adjust lung … Continue reading On the tasseography of lung function genes<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[2585,2584],"class_list":["post-3406","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-gwas","tag-lung-function"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/3406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=3406"}],"version-history":[{"count":8,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/3406\/revisions"}],"predecessor-version":[{"id":3419,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/3406\/revisions\/3419"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=3406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=3406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=3406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}