{"id":389,"date":"2006-11-17T18:04:44","date_gmt":"2006-11-17T16:04:44","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2006\/11\/17\/best-of-two-worlds\/"},"modified":"2006-11-20T18:29:08","modified_gmt":"2006-11-20T16:29:08","slug":"best-of-two-worlds","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/best-of-two-worlds\/","title":{"rendered":"Best of two worlds"},"content":{"rendered":"<p>Finally, linkage and association data can be used together after <a href=\"http:\/\/www.nature.com\/ng\/journal\/v38\/n9\/abs\/ng1863.htm\">downloading<\/a> new software using <a href=\"http:\/\/genomics.med.upenn.edu\/genotypeinference\">genotype inference<\/a>.<\/p>\n<blockquote><p>\nIt reduces the number of genotyping reactions and increases the power of genome-wide association studies.  Our method combines sparse marker data from a linkage scan and high-resolution SNP genotypes for several individuals to infer genotypes for related individuals.\n<\/p><\/blockquote>\n<p>Sure, we<\/p>\n<ul>\n<li>could already test association only in linked <a href=\"http:\/\/biostatistics.oxfordjournals.org\/cgi\/content\/abstract\/5\/2\/307\">families<\/a><\/li>\n<li>knew that <a href=\"http:\/\/www.journals.uchicago.edu\/AJHG\/journal\/issues\/v78n2\/42937\/brief\/42937.abstract.html\">linkage genome scans<\/> will improve the power of association<\/a><\/li>\n<li> could evaluate by <a href=\"http:\/\/hg-wen.uchicago.edu\/software.html\">stepc<\/a> if a polymorphisms explains a linkage result<\/li>\n<p>but this seems to be the best recycling for our old fashioned linkage data. Yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 09.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Finally, linkage and association data can be used together after downloading new software using genotype inference. It reduces the number of genotyping reactions and increases the power of genome-wide association studies. Our method combines sparse marker data from a linkage scan and high-resolution SNP genotypes for several individuals to infer genotypes for related individuals. Sure, &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/best-of-two-worlds\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Best of two worlds<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2945,4,208,209,211,210,212,207],"class_list":["post-389","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-genetics-biology","tag-population-epidemiology","tag-association_data","tag-genotyping","tag-high_resolution","tag-inference","tag-linkage-disequilibrium","tag-snp"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=389"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/389\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}