{"id":396,"date":"2006-11-18T19:07:13","date_gmt":"2006-11-18T17:07:13","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2006\/11\/18\/indelligent\/"},"modified":"2006-11-18T19:07:13","modified_gmt":"2006-11-18T17:07:13","slug":"indelligent","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/indelligent\/","title":{"rendered":"INDELligent"},"content":{"rendered":"<p>I am detailing in a forthcoming paper in &#8220;Allergy&#8221;, that the contradicting results found with ADAM33 (the first positionally cloned asthma gene) probably results from a rather poor design of all follow-up studies.<br \/>\nIt does not make so much sense to repeat over and over the same few SNP marker; instead a full resquencing of the linkage region would be necessary. From the analysis of public LD maps it is even possible that neighboring genes may be responsible for the observed associations.<br \/>\nI have also doubts if the SNP-centric view is always leading to success. BTW there is a new database of over 400,000 non-reduandt indels of which 280,000 are validated by comparison with other human or chimpanzee genomes (see <a href=\"http:\/\/www.genome.org\/cgi\/content\/full\/16\/9\/1182\">Mills et al.<\/a>, the indels are available in dbSNP under the &#8220;Devine_lab&#8221; handle).<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>I am detailing in a forthcoming paper in &#8220;Allergy&#8221;, that the contradicting results found with ADAM33 (the first positionally cloned asthma gene) probably results from a rather poor design of all follow-up studies. It does not make so much sense to repeat over and over the same few SNP marker; instead a full resquencing of &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/indelligent\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">INDELligent<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[2948,2945,83,220,219,221,207],"class_list":["post-396","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-asthma-allergy","tag-genetics-biology","tag-asthma","tag-chimpanzee","tag-dbsnp","tag-indel","tag-snp"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=396"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/396\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}