{"id":405,"date":"2006-11-22T14:25:02","date_gmt":"2006-11-22T12:25:02","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2006\/11\/22\/men-rsponding-to-women\/"},"modified":"2006-11-22T14:49:51","modified_gmt":"2006-11-22T12:49:51","slug":"men-rsponding-to-women","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/men-rsponding-to-women\/","title":{"rendered":"Men r&#8217;sponding to women"},"content":{"rendered":"<p>We know much about the differences between <a href=\"http:\/\/sciencenow.sciencemag.org\/cgi\/content\/full\/2005\/1107\/2\">men and women<\/a> &#8211; the <a href=\"http:\/\/www.nature.com\/nrg\/journal\/v7\/n8\/abs\/nrg1903.html\">X is the default pathway<\/a> and the Y under the microscope looks as worn down and &#8220;<a href=\"http:\/\/www.washingtonpost.com\/wp-dyn\/content\/article\/2005\/09\/04\/AR2005090400867.html\">misshapen as a stubbed-out cheroot<\/a>&#8220;. There turns out to be something really new. So far all effects of Y genes on sex determination have been attributed to SRY, the testis determining gene (NR0B1, FOXL2 and WNT04 are probably ovary-determining).<br \/>\nThe careful analysis of an Italian pedigree now described a new gene that can reversal XX to male when being disrupted: It is R-spondin 1 (or RSPO1), a growth factor that may act through \u00df-catenin stabilization and synergize with Wnt.<br \/>\nDo you know renember the <a href=\"http:\/\/www.life.uiuc.edu\/bio100\/lectures\/fall97lects\/Y-chromosome.html\">nice cartoon<\/a> of the Y chromosome<\/a> with the  HUH? selective hearing loss ;-) it is finally RSPO1. Yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 07.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>We know much about the differences between men and women &#8211; the X is the default pathway and the Y under the microscope looks as worn down and &#8220;misshapen as a stubbed-out cheroot&#8220;. There turns out to be something really new. So far all effects of Y genes on sex determination have been attributed to &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/men-rsponding-to-women\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Men r&#8217;sponding to women<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2945,257,254,256,252,253,255,251],"class_list":["post-405","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-genetics-biology","tag-rspo1","tag-differences_between_men_and_women","tag-pedigree","tag-selective_hearing_loss","tag-sex_determination","tag-sry","tag-y_chromosome"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=405"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/405\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}