{"id":4171,"date":"2010-02-24T10:52:21","date_gmt":"2010-02-24T08:52:21","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=4171"},"modified":"2015-04-29T15:38:41","modified_gmt":"2015-04-29T14:38:41","slug":"close-the-calcium-channel-to-get-rid-of-allergy","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2010\/02\/close-the-calcium-channel-to-get-rid-of-allergy\/","title":{"rendered":"Close the calcium channel to get rid of allergy?"},"content":{"rendered":"

Hopefully the auto-loader at the bottom will pick some previous posts here about calcium, vitamin D and allergy; these may be necessary for the background of a new study published in the American Journal of Respiratory and Critical Care Medicine last week<\/a><\/p>\n

We looked for Cav1 channel expression in Th2 and Th1-cells by real-time PCR and Western blotting. We sequenced the isoforms expressed by Th2-cells and tested whether Cav1 antisense oligodeoxynucleotides (Cav1AS) affected Ca2+ signaling and cytokine production […] mouse Th2 but not Th1-cells expressed Cav1.2 and Cav1.3 channels. Th2-cells transfected with Cav1AS had impaired Ca2+ signaling and cytokine production, and lost their ability to induce airway inflammation upon adoptive transfer.<\/p><\/blockquote>\n

This highlights again the close connection of the calcium system to immunology. While the earlier TRPM4<\/a> story was basically about mast cells, we now arrived at Th2 cells, yea, yea.<\/p>\n

Addendum 29 April 2015<\/h3>\n

It took some time. Science<\/a> has a paper on Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma” by Yarova et al. writing about antagonists of the calcium-sensing receptor<\/p>\n

\nWe show that polycations and elevated extracellular calcium activate the human recombinant and native calcium-sensing receptor (CaSR), leading to intracellular calcium mobilization … These effects can be prevented by CaSR antagonists, termed calcilytics. Moreover, asthmatic patients and allergen- sensitized mice expressed more CaSR in ASMs than did their healthy counterparts … Thus, calcilytics may represent effective asthma therapeutics.\n<\/p><\/blockquote>\n

I don’t know, if the last statement is really warranted but – as written 5 years ago – there is a super tight connection of calcium and vitamin D to allergy.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 16.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Hopefully the auto-loader at the bottom will pick some previous posts here about calcium, vitamin D and allergy; these may be necessary for the background of a new study published in the American Journal of Respiratory and Critical Care Medicine last week We looked for Cav1 channel expression in Th2 and Th1-cells by real-time PCR … Continue reading Close the calcium channel to get rid of allergy?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[1287],"class_list":["post-4171","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/4171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=4171"}],"version-history":[{"count":6,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/4171\/revisions"}],"predecessor-version":[{"id":7625,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/4171\/revisions\/7625"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=4171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=4171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=4171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}