{"id":443,"date":"2006-11-28T11:58:40","date_gmt":"2006-11-28T09:58:40","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2006\/11\/28\/better-than-the-delphi-oracle\/"},"modified":"2006-11-28T11:58:40","modified_gmt":"2006-11-28T09:58:40","slug":"better-than-the-delphi-oracle","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/better-than-the-delphi-oracle\/","title":{"rendered":"Better than the Delphi oracle"},"content":{"rendered":"<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&#038;cmd=Retrieve&#038;dopt=AbstractPlus&#038;list_uids=17057710&#038;query_hl=4&#038;itool=pubmed_docsum\">A new paper<\/a> shows a nice workflow how to do an <em>in vitro<\/em> prediction which drug will suppress a certain tumor. The authors are simply linking the phenotype of the cell line &#8220;50% inhibitory concentration by drug X&#8221; with its expression signature. The good news are that doing both in one vial (phenotyping and expression analysis) is leading to excellent results.<\/p>\n<p><a class=\"imagelink\" href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2006\/11\/genomicsignature.png\" title=\"\" data-rel=\"key-image-0\" data-rl_title=\"\" data-rl_caption=\"\"><img decoding=\"async\" id=\"image442\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2006\/11\/genomicsignature.thumbnail.png\" alt=\"genomicsignature.png\" \/><\/a><\/p>\n<p>Is there any trick to do this also system-wide e.g. for the metabolism of a substance and its signalling pathway? Pharmacogenetics would greatly benefit from such an approach, nay, nay.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 30.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>A new paper shows a nice workflow how to do an in vitro prediction which drug will suppress a certain tumor. The authors are simply linking the phenotype of the cell line &#8220;50% inhibitory concentration by drug X&#8221; with its expression signature. The good news are that doing both in one vial (phenotyping and expression &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/11\/better-than-the-delphi-oracle\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Better than the Delphi oracle<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2945,4,319,318],"class_list":["post-443","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-genetics-biology","tag-population-epidemiology","tag-expression-profiling","tag-phenotyping"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=443"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/443\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}