{"id":4485,"date":"2010-06-12T07:23:11","date_gmt":"2010-06-12T05:23:11","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=4485"},"modified":"2011-01-19T17:15:01","modified_gmt":"2011-01-19T15:15:01","slug":"genes-on-the-fast-lane","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2010\/06\/genes-on-the-fast-lane\/","title":{"rendered":"Genes on the fast lane"},"content":{"rendered":"<p>I need to refer here to a <a href=\"https:\/\/www.wjst.de\/blog\/2007\/02\/06\/human-genes-on-the-move\/\">post 3 years ago<\/a> and the <a href=\"http:\/\/www.plosmedicine.org\/article\/info%3Adoi%2F10.1371%2Fjournal.pmed.0040072\">medical literature<\/a> that genes frequencies may have changed rapidly between <a href=\"http:\/\/ije.oxfordjournals.org\/cgi\/reprint\/29\/6\/1031\">generations<\/a>.<br \/>\nAny empirical proof of this hypothesis, however, is scarce so far. Or I have to say, until this week, when I found a study published earlier in PLoS ONE that tackles this problem: <a href=\"http:\/\/www.plosone.org\/article\/info:doi%2F10.1371%2Fjournal.pone.0007795\"><em>Selection for Genetic Variation Inducing Pro-Inflammatory Responses under Adverse Environmental Conditions in a Ghanaian Population<\/em><\/a><!--more--><\/p>\n<blockquote><p>Here we show that an IL10 haplotype that associated with a pro-inflammatory innate immune response, characterised by low IL-10 and high TNFa levels, was enriched among Ghanaian elders. Furthermore, in an environment where the source of drinking water (wells\/rivers vs. boreholes) influences mortality risks, we observed that carriers of the pro-inflammatory haplotype have a survival advantage when drinking from wells\/rivers but a disadvantage when drinking from boreholes.<\/p><\/blockquote>\n<p>Yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 15.05.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>I need to refer here to a post 3 years ago and the medical literature that genes frequencies may have changed rapidly between generations. Any empirical proof of this hypothesis, however, is scarce so far. Or I have to say, until this week, when I found a study published earlier in PLoS ONE that tackles &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2010\/06\/genes-on-the-fast-lane\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Genes on the fast lane<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[2599,2644],"class_list":["post-4485","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology","tag-evo-devo","tag-heterozygote-advantage"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/4485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=4485"}],"version-history":[{"count":10,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/4485\/revisions"}],"predecessor-version":[{"id":5474,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/4485\/revisions\/5474"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=4485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=4485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=4485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}