{"id":460,"date":"2006-12-04T15:19:32","date_gmt":"2006-12-04T13:19:32","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2006\/12\/04\/who-will-survive\/"},"modified":"2006-12-04T15:21:28","modified_gmt":"2006-12-04T13:21:28","slug":"who-will-survive","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/12\/who-will-survive\/","title":{"rendered":"Who will survive?"},"content":{"rendered":"<p>When looking at gene variants in a population we may forget that even having a perfect sampling scheme this will not be an unbiased view of the human genome. Earlier studies suggested that up to 75% of conceptions are lost during early development; a further indicator of an biased view are unexplained cases of departure from Hardy-Weinberg equilibrium.<br \/>\nSelective survival during early pregnancy is still a <em>terra incognita<\/em> and except of studies in the Hutterites I am not aware of any (modern) study that looked at selective survival.<br \/>\nA study of <a href=\"http:\/\/www.journals.uchicago.edu\/AJHG\/journal\/contents\/v79n6.html\">Grant Montgomery<\/a> now shows fresh  data on genomewide allele sharing in 1,592 DZ twins from Australia and 336 DZ pairs from the Netherlands.<br \/>\nIt is somewhat disappointing that there is no excess allele sharing in the HLA region nor somewhere else in the genome. Maybe further studies can do that a high resolution than with just 359 microsatellite marker? <\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 28.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>When looking at gene variants in a population we may forget that even having a perfect sampling scheme this will not be an unbiased view of the human genome. Earlier studies suggested that up to 75% of conceptions are lost during early development; a further indicator of an biased view are unexplained cases of departure &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/12\/who-will-survive\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Who will survive?<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2945,4,370,366,364,211,369,368,363,367,365],"class_list":["post-460","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-genetics-biology","tag-population-epidemiology","tag-conceptions","tag-gene_variants","tag-hardy_weinberg_equilibrium","tag-high_resolution","tag-microsatellite","tag-sampling_scheme","tag-selective_survival","tag-terra_incognita","tag-twin_pairs"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/460","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=460"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/460\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=460"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=460"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=460"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}