{"id":5014,"date":"2010-11-02T14:16:42","date_gmt":"2010-11-02T12:16:42","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=5014"},"modified":"2010-11-03T09:04:11","modified_gmt":"2010-11-03T07:04:11","slug":"do-we-all-have-compensated-monogenic-traits","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2010\/11\/do-we-all-have-compensated-monogenic-traits\/","title":{"rendered":"Do we all have (compensated) monogenic traits?"},"content":{"rendered":"<p>I have made several attempts here to estimate the number of somatic mutations: 3,93 <a href=\"https:\/\/www.wjst.de\/blog\/2007\/04\/22\/393-mutations-mb\/\">mutations \/ Mb<\/a>(2007), <a href=\"https:\/\/www.wjst.de\/blog\/2007\/01\/12\/a-longe-fuse\/\">the long fuse<\/a> (2007), about the cancer <a href=\"https:\/\/www.wjst.de\/blog\/2010\/01\/05\/evolutionary-legacy\/\">the legacy<\/a> (2010) or <a href=\"https:\/\/www.wjst.de\/blog\/2010\/01\/20\/one-mutation-every-day\/\">1\/day<\/a> in the life of a mutation (2010) but the best summary <a href=\"http:\/\/www.nature.com\/nature\/journal\/v467\/n7319\/full\/nature09534.html\">now<\/a> comes from the <a href=\"http:\/\/www.1000genomes.org\/page.php\">1000 genomes<\/a><\/p>\n<blockquote><p>From the two trios, we directly estimate the rate of de novo germline base substitution mutations to be approximately 10^-8 per base pair per generation.<\/p><\/blockquote>\n<p>along with the fact that<\/p>\n<blockquote><p>\non average, each person is found to carry approximately 250 to 300 loss-of-function variants in annotated genes and 50 to 100 variants previously implicated in inherited disorders.\n<\/p><\/blockquote>\n<p>which raises some doubts that these 50 to 100 have only been implicated but not proven&#8230;<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 10.06.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>I have made several attempts here to estimate the number of somatic mutations: 3,93 mutations \/ Mb(2007), the long fuse (2007), about the cancer the legacy (2010) or 1\/day in the life of a mutation (2010) but the best summary now comes from the 1000 genomes From the two trios, we directly estimate the rate &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2010\/11\/do-we-all-have-compensated-monogenic-traits\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Do we all have (compensated) monogenic traits?<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[813],"class_list":["post-5014","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-mutation_rate"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=5014"}],"version-history":[{"count":8,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5014\/revisions"}],"predecessor-version":[{"id":5022,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5014\/revisions\/5022"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=5014"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=5014"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=5014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}