{"id":5520,"date":"2011-02-23T07:17:26","date_gmt":"2011-02-23T05:17:26","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=5520"},"modified":"2011-02-23T07:18:21","modified_gmt":"2011-02-23T05:18:21","slug":"i-am-confused-but-on-a-higher-level","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2011\/02\/i-am-confused-but-on-a-higher-level\/","title":{"rendered":"I am confused but on a higher level"},"content":{"rendered":"<p>A <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21325945\">new study in the AJRCCM<\/a> shows that eosinophils are dispensable for allergic remodeling and immunity<!--more--><\/p>\n<blockquote><p>\nWe elucidated the requirement for eosinophils in the generation of allergic sensitization, airway inflammation, and remodeling in a model involving chronic respiratory exposure to house dust mite (HDM).<br \/>\nWe used three methods to selectively eliminate eosinophils, a depleting antibody (anti-CCR3), and two strains of eosinophil-deficient mice (dblGATA and the transgenic line PHIL).<br \/>\nAnti-CCR3 treatment markedly reduced pulmonary eosinophilia (> 80%) over the course of HDM exposure but had no effect on the remaining inflammatory response&#8230; Collectively, these data demonstrate that, at variance with the prevailing paradigm, eosinophils play negligible roles in the generation of HDM-induced allergic immunity and airway remodeling.\n<\/p><\/blockquote>\n<p>which largely contradicts <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19198610?ordinalpos=2&#038;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\">our findings from 2007<\/a> where  SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma. Maybe that new study is just a mouse study that does not relate to human pathology?<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 26.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>A new study in the AJRCCM shows that eosinophils are dispensable for allergic remodeling and immunity &nbsp; CC-BY-NC Science Surf , accessed 26.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[],"class_list":["post-5520","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=5520"}],"version-history":[{"count":4,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5520\/revisions"}],"predecessor-version":[{"id":5531,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5520\/revisions\/5531"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=5520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=5520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=5520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}