{"id":562,"date":"2007-01-06T11:13:13","date_gmt":"2007-01-06T09:13:13","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/01\/06\/shut-up\/"},"modified":"2007-01-08T08:55:39","modified_gmt":"2007-01-08T06:55:39","slug":"vivat-rex","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/01\/vivat-rex\/","title":{"rendered":"Vivat rex"},"content":{"rendered":"<p>Ever since I heard 1976 about the Lyon hypothesis (described already in 1961 by Mary Frances Lyon) of X inactivation I wondered how this works on a molecular level &#8211; locking this chromosome in a separate nuclear compartment, condense it or encase it? Silencing a whole chromosome probably needs a concerted action of higher order DNA structure, histone code modification and primary sequence features. The last seems to be <a href =\"http:\/\/www.nature.com\/nature\/journal\/v444\/n7119\/abs\/nature05338.html\">indeed relevant<\/a> as C. elegans X has a target for gene expression repression by the dosage compensation complex &#8211; small rex motifs (X recruitment elements) ?CAGGGG and ?GTAATTG. The strength of DCC recruitment is correlated with rex motif number BUT rex motifs are not enriched on X &#8211; so certainly more features need to synergize for X repression. Yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 07.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Ever since I heard 1976 about the Lyon hypothesis (described already in 1961 by Mary Frances Lyon) of X inactivation I wondered how this works on a molecular level &#8211; locking this chromosome in a separate nuclear compartment, condense it or encase it? Silencing a whole chromosome probably needs a concerted action of higher order &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/01\/vivat-rex\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Vivat rex<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2945,544,546,545,549,550,547,548,543],"class_list":["post-562","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-genetics-biology","tag-c_elegans","tag-chromosome","tag-histone_code","tag-lyon","tag-motif","tag-motifs","tag-repression","tag-rex"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=562"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/562\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}