{"id":5925,"date":"2012-01-19T12:18:58","date_gmt":"2012-01-19T10:18:58","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=5925"},"modified":"2012-01-19T12:19:46","modified_gmt":"2012-01-19T10:19:46","slug":"the-5-most-important-papers-on-vitamin-d-and-respiratory-infections-in-asthma","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2012\/01\/the-5-most-important-papers-on-vitamin-d-and-respiratory-infections-in-asthma\/","title":{"rendered":"The 5 most important papers on vitamin D and respiratory infections in asthma"},"content":{"rendered":"

Ginde AA et al., Vitamin D, respiratory infections, and asthma, Current Allergy and Asthma Reports 2009<\/a>:<\/p>\n

Substantial evidence now indicates that vitamin D may enhance the innate immune response and protect against respiratory infection. The human cathelicidin hCAP- 18 appears to have a particularly important role in the vitamin D\u2013mediated mechanism against infection. Additionally, early evidence suggests that vitamin D modulates regulatory T-cell activity and IL-10 production, which are critical to the Th1\u2013Th2 balance. These findings may be particularly important in the pathogenesis, control, and severity of asthma. However, much of these data are in cell culture or observational clinical studies, and the observed inverse associations may be due to residual confound- ing, such as from outdoor physical activity. Future laboratory and clinical studies, with a special focus on children and adults with asthma, will help to clarify the vitamin D\u2013asthma association.<\/p><\/blockquote>\n

JJ Cannell et al., Epidemic influenza and vitamin D, Epidemiol Infect 2006<\/a><\/p>\n

…it is premature to recommend vitamin D for either the prevention or treatment of viral respiratory infections. It is not, however, too early to recommend that health-care providers aggressively diagnose and adequately treat vitamin D deficiency. <\/p><\/blockquote>\n

Finklea JD, Vitamin D and chronic lung disease, Adv Nutr 2011<\/a><\/p>\n

At this time, there is a considerable amount of evidence that implicates vitamin D as a factor associated with various chronic lung diseases. The question remains whether vita- min D deficiency contributes to the etiology of lung disease or if vitamin D deficiency is simply a manifestation of the lung disease and\/or its treatment. As research in this field unfolds, vitamin D supplementation will need to be evalu- ated in larger trials focused on specific respiratory diseases.\n<\/p><\/blockquote>\n

Lehouck AT et al., High doses of vitamin d to reduce exacerbations in chronic obstructive pulmonary disease, Ann Int Med 2012<\/a><\/p>\n

High-dose vitamin D supplementation in a sample of patients with COPD did not reduce the incidence of exacerbations. In participants with severe vitamin D deficiency at baseline, supplementation may reduce exacerbations.<\/p><\/blockquote>\n

Li-Ng M, eta la. A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections, Epidemiol Infect. 2009<\/a><\/p>\n

There was no benefit of vitamin D3 supplementation in decreasing the incidence or severity of symptomatic URIs during winter. Further studies are needed to determine the role of vitamin D in infection.<\/p><\/blockquote>\n

WHO<\/a> 19 Jan 2012:<\/p>\n

Some studies have suggested that vitamin D supplementation can decrease the frequency and severity of respiratory infections among children. There is a need for further research before recommendations can be made.<\/p><\/blockquote>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 26.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Ginde AA et al., Vitamin D, respiratory infections, and asthma, Current Allergy and Asthma Reports 2009: Substantial evidence now indicates that vitamin D may enhance the innate immune response and protect against respiratory infection. The human cathelicidin hCAP- 18 appears to have a particularly important role in the vitamin D\u2013mediated mechanism against infection. Additionally, early … Continue reading The 5 most important papers on vitamin D and respiratory infections in asthma<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[2744,2745],"class_list":["post-5925","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin","tag-infection","tag-pneumonia"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=5925"}],"version-history":[{"count":4,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5925\/revisions"}],"predecessor-version":[{"id":5929,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/5925\/revisions\/5929"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=5925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=5925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=5925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}