{"id":6427,"date":"2013-11-16T15:10:27","date_gmt":"2013-11-16T14:10:27","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=6427"},"modified":"2016-11-12T17:48:09","modified_gmt":"2016-11-12T16:48:09","slug":"single-cell-genomics-update","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2013\/11\/single-cell-genomics-update\/","title":{"rendered":"Single cell genomics update"},"content":{"rendered":"<p><a href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2013\/11\/talk.jpg\" data-rel=\"key-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-6430\" alt=\"talk\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2013\/11\/talk.jpg\" width=\"551\" height=\"671\" srcset=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2013\/11\/talk.jpg 551w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2013\/11\/talk-410x500.jpg 410w\" sizes=\"auto, (max-width: 551px) 100vw, 551px\" \/><\/a> I have been attending yesterday an interesting talk of <a href=\"http:\/\/thebigone.stanford.edu\/publications_home.htm\">Stephen Quake<\/a>. Yes, this was a Leica sponsored event, but not about photography, it was about single cell genomics. I was always interested in that field and quite impressed by the Quake approach. These biology-baptized mathematicians and physicists can easily compete with whole research centers and a 100fold head count.<\/p>\n<p>The commercial spin-off is <a href=\"http:\/\/www.fluidigm.com\/single-cell-genomics.html\">fluidigm.com<\/a>\u00a0while his main research is not only sequencing of the fastest moving bacterium but also an estimate of mutations in his own haploid (sperm) genomes, single cell expression along with single cell methylation patterns.<\/p>\n<p>One of the really exciting questions is the mismatch of single cell RNA and protein content where I need to go for some papers that I wasn&#8217;t aware off. Another excellent idea is the clustering of single cell expression profiles. This is already leading to new classes of cells and a probably much more valid approach than using random? surface markers as <a href=\"http:\/\/www.youtube.com\/embed\/xaz5ftvZCyI?\">immunologists<\/a> usually do, yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 11.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>I have been attending yesterday an interesting talk of Stephen Quake. Yes, this was a Leica sponsored event, but not about photography, it was about single cell genomics. I was always interested in that field and quite impressed by the Quake approach. These biology-baptized mathematicians and physicists can easily compete with whole research centers and &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2013\/11\/single-cell-genomics-update\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Single cell genomics update<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-6427","post","type-post","status-publish","format-standard","hentry","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=6427"}],"version-history":[{"count":10,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6427\/revisions"}],"predecessor-version":[{"id":6438,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6427\/revisions\/6438"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=6427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=6427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=6427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}