{"id":6738,"date":"2014-02-21T11:29:46","date_gmt":"2014-02-21T10:29:46","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=6738"},"modified":"2016-10-12T18:56:41","modified_gmt":"2016-10-12T17:56:41","slug":"bullet-points-for-future-allergy-research","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2014\/02\/bullet-points-for-future-allergy-research\/","title":{"rendered":"Bullet points for future allergy research"},"content":{"rendered":"<p>Maybe this is a difficult task &#8211; defining an agenda for future research. Here are some thoughts as we don&#8217;t know the reasons for the allergy epidemic even after 100 years of research. And we don&#8217;t have any cure yet, there is some relief of symptoms and there are some limited curative efforts but we don&#8217;t have any real understanding of what is going on. The following research areas may therefore be identified in NON-therapeutic research:<!--more--><\/p>\n<ul>\n<li>Allergologists have only limited knowledge of immunology and most immunologists have no interest in allergy.<\/li>\n<li>Animal models and in vitro studies have nearly zero value for human allergy (different MHC, different IgE receptor, different co-conditions).<\/li>\n<li>Pollen and air pollution effects are nice to know but not necessary to understand the initiation of allergy.<\/li>\n<li>The hygiene hypothesis has severe shortcomings while iatrogenic causes (antibiotics, vitamin D, paracetamol) get an increasing attention.<\/li>\n<li>We need RCTs, no lengthy reviews and editorials.<\/li>\n<li>Wrong time-points have been examined in recent epidemiological studies as allergy develops in utero or the first few months. Late onset allergy (&gt;60 y) has also never been examined systematically. We need new pregnancy and geriatric cohorts.<\/li>\n<li>Epidemiology selected wrong study locations. IgE and allergy needs to be examined in Africa on the background of helminth biology.<\/li>\n<li>Genetics did not deliver as GWAS chips included only frequent variants and tested mainly European populations. We need full genome sequencing and\/or rare variant GWAS including strong bioinformatics support.<\/li>\n<li>More tools need to be tested: whole genome methylation screening, RNA sequencing of single cell transcripts, RNA gut and skin bacterial profiling are under-used methods so far.<\/li>\n<\/ul>\n<p>I believe that many of these issues can be solved if allergy research can be restructured from an institutional (epidemiology, human genetics, immunology, dermatology&#8230;) approach to a task\/working group related approach.<\/p>\n<p>It is not important to fund a herd of horses but to identify the winning horse.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 08.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Maybe this is a difficult task &#8211; defining an agenda for future research. Here are some thoughts as we don&#8217;t know the reasons for the allergy epidemic even after 100 years of research. And we don&#8217;t have any cure yet, there is some relief of symptoms and there are some limited curative efforts but we &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2014\/02\/bullet-points-for-future-allergy-research\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Bullet points for future allergy research<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,20],"tags":[199,1771,2044,2837],"class_list":["post-6738","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-note-worthy","tag-allergy","tag-failure","tag-research","tag-success"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=6738"}],"version-history":[{"count":7,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6738\/revisions"}],"predecessor-version":[{"id":8434,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6738\/revisions\/8434"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=6738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=6738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=6738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}