{"id":6870,"date":"2014-04-04T15:34:05","date_gmt":"2014-04-04T14:34:05","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=6870"},"modified":"2014-04-16T14:04:29","modified_gmt":"2014-04-16T13:04:29","slug":"why-i-believe-in-twin-studies","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2014\/04\/why-i-believe-in-twin-studies\/","title":{"rendered":"Why I believe in twin studies"},"content":{"rendered":"<p><a href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0692.jpg\" data-rel=\"key-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6872\" alt=\"20120609-DS7_0692\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0692.jpg\" width=\"1200\" height=\"798\" srcset=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0692.jpg 1200w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0692-620x412.jpg 620w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0692-751x500.jpg 751w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/a><\/p>\n<p><a href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0726.jpg\" data-rel=\"key-image-1\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6871\" alt=\"Zwillingstreffen im Pillerseetal  7. Juni 2012 - 9. Juni 2012\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0726.jpg\" width=\"1200\" height=\"675\" srcset=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0726.jpg 1200w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0726-620x348.jpg 620w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2014\/04\/20120609-DS7_0726-888x500.jpg 888w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/a><\/p>\n<p>These are some pictures that I took roughly two years ago on twin meeting in Austria. <a href=\"http:\/\/en.wikipedia.org\/wiki\/Twin_study\">Twin studies<\/a> give us some unique opportunities like in <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24734033\">this recent paper<\/a><\/p>\n<blockquote><p>We performed a genome-wide study to investigate differences in (i) DNA methylation (using a custom tiled four-plex array containing tiled 50-mers 19,084 randomly chosen methylation sites), (ii) copy number variation (CNV) (with a chip including markers derived from the 1000 Genomes Project, all three HapMap phases, and recently published studies), and\/or (iii) gene expression (by whole-genome expression arrays). Based on the results obtained from these three approaches we utilized quantitative PCR to compare the expression of candidate genes. Importantly, our data support consistent differences in discordant twins and siblings for the (i) methylation profiles of 60 gene regions, (ii) CNV of 10 genes, and (iii) the expression of 2 interferon-dependent genes. <\/p><\/blockquote>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 22.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>These are some pictures that I took roughly two years ago on twin meeting in Austria. Twin studies give us some unique opportunities like in this recent paper We performed a genome-wide study to investigate differences in (i) DNA methylation (using a custom tiled four-plex array containing tiled 50-mers 19,084 randomly chosen methylation sites), (ii) &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2014\/04\/why-i-believe-in-twin-studies\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Why I believe in twin studies<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-6870","post","type-post","status-publish","format-standard","hentry","category-computer-software"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=6870"}],"version-history":[{"count":5,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6870\/revisions"}],"predecessor-version":[{"id":6950,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6870\/revisions\/6950"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=6870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=6870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=6870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}