{"id":699,"date":"2007-02-27T20:00:42","date_gmt":"2007-02-27T18:00:42","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/02\/27\/an-update-on-the-barker-hypothesis\/"},"modified":"2007-03-12T12:44:58","modified_gmt":"2007-03-12T11:44:58","slug":"an-update-of-the-barker-hypothesis","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/02\/an-update-of-the-barker-hypothesis\/","title":{"rendered":"An update of the Barker hypothesis"},"content":{"rendered":"

Do you know the Barker hypothesis? It says that early life events may induce later disease. A new study in the Eur J Clin Nutr<\/a> now reports<\/p>\n

\nChildren whose mothers had a 25(OH)-vitamin D concentration in pregnancy >75 nmol\/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15\u00e2\u20ac\u201c9.29, P=0.025) and asthma at age 9 years (OR 5.40, 95% CI, 1.09\u00e2\u20ac\u201c26.65, P=0.038) compared to children whose mothers had a concentration of <30 nmol\/l.\n<\/p><\/blockquote>\n

These are quite remarkable results. I wonder only why two forthcoming studies click<\/a> + click<\/a> using food frequency questionnaires will describe only a reduction of respiratory infection rates (which is not too bad in the context of the hygiene hypothesis) with no effects on allergy. <\/p>\n

Food intake measures are probably not good enough for internal dose estimates<\/a> as main source of vitamin D production is sunlight, isn\u00c2\u00b4t it?<\/p>\n

Addendum<\/h3>\n

12 March 2007 – the long awaited AJCN<\/a> paper is now out. I have already feared that stratification by FFQ is only partially relevant. Indeed, the authors could have used also college graduate level which increased with intake catgeories 1-2-3-4 from 53-74-80-82% with all the problems by SES<\/a> dependency (and not corrected for in model 2+3 in table 2 or model A…D in table 3). The discussion seems to be also far away from being an objective report on the immunology of vitamin D actions…<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 10.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Do you know the Barker hypothesis? It says that early life events may induce later disease. A new study in the Eur J Clin Nutr now reports Children whose mothers had a 25(OH)-vitamin D concentration in pregnancy >75 nmol\/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15\u00e2\u20ac\u201c9.29, … Continue reading An update of the Barker hypothesis<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[],"class_list":["post-699","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=699"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/699\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}