{"id":6991,"date":"2014-05-07T06:29:41","date_gmt":"2014-05-07T05:29:41","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=6991"},"modified":"2014-05-07T06:38:05","modified_gmt":"2014-05-07T05:38:05","slug":"the-human-disease-network-no-need-to-call-it-diseasome","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2014\/05\/the-human-disease-network-no-need-to-call-it-diseasome\/","title":{"rendered":"The human disease network (no need to call it diseasome)"},"content":{"rendered":"

There was the\u00a02077 Goh PNAS paper<\/a> using that title. And it is a sound approach probably better than any\u00a0division of chapters in Harrison’s Internal Medicine!<\/p>\n

A network of disorders and disease genes linked by known disorder\u2013gene associations offers a platform to explore in a single graph-theoretic framework all known phenotype and disease gene associations, indicating the common genetic origin of many diseases. Genes associated with similar disorders show both higher likelihood of physical interactions between their products and higher expression profiling similarity for their transcripts, supporting the existence of distinct disease-specific functional modules. We find that essential human genes are likely to encode hub proteins and are expressed widely in most tissues.<\/p><\/blockquote>\n

I found this on a slide at the recent vitamin D congress in London and was just interested to see, how often this paper has been cited. So far as I remember only the Barabasi<\/a> update. And the result is impressing<\/p>\n

\"Bildschirmfoto<\/p>\n

Getting a quick overview<\/a> of the field isn’t easy. It looks like that similar phenotypes are derived from functionally similar disease-genes.\u00a0Genes associated to a single disorder are frequently \u00a0functionally related. While most most disease genes are no hubs, variants\u00a0in a few\u00a0hub genes may rise baseline risks for several\u00a0diseases.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 02.05.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

There was the\u00a02077 Goh PNAS paper using that title. And it is a sound approach probably better than any\u00a0division of chapters in Harrison’s Internal Medicine! A network of disorders and disease genes linked by known disorder\u2013gene associations offers a platform to explore in a single graph-theoretic framework all known phenotype and disease gene associations, indicating … Continue reading The human disease network (no need to call it diseasome)<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,9],"tags":[2855,1778,2854,115],"class_list":["post-6991","post","type-post","status-publish","format-standard","hentry","category-philosophy-of-science","category-computer-software","tag-classification","tag-disease","tag-diseasome","tag-network"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=6991"}],"version-history":[{"count":7,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6991\/revisions"}],"predecessor-version":[{"id":7001,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/6991\/revisions\/7001"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=6991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=6991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=6991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}