{"id":7275,"date":"2014-11-07T12:15:53","date_gmt":"2014-11-07T11:15:53","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=7275"},"modified":"2014-11-07T13:01:00","modified_gmt":"2014-11-07T12:01:00","slug":"premature-epiphysis-closure-by-high-vitamin-d-supplementation","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2014\/11\/premature-epiphysis-closure-by-high-vitamin-d-supplementation\/","title":{"rendered":"Premature epiphysis closure by high vitamin D supplementation?"},"content":{"rendered":"

Having been asked this question, I was only aware of the fact that premature epiphysis closure\u00a0is\u00a0a side effect of isotretinoin therapy in children (Tran 2008<\/a>).
\nWhile DELAYED\u00a0epiphysis closure is known for rickets, it is an interesting question if vitamin D supplements given to adolescents will be leading to a premature end of longitudinal growth.\u00a0Maybe this is\u00a0also a difficult question as the answer will depend on long-time vitamin D, calcium and phosphate status; it will depend on dose and application scheme of any vitamin D supplement. And it will depend to some extent on\u00a0the genetically determined vitamin D hydroxylase activity.\u00a0The ultimate textbook (Feldman, Vitamin D, p864<\/a>) writes<\/p>\n

With treatment the unmineralized osteoid of the growth plate of the metaphysics ad epiphysis will mineralize.<\/p><\/blockquote>\n

This is in line with original research in rats (Boris 1978<\/a>) showing<\/p>\n

The results …\u00a0indicate that the administration of la,25-(OH)2-D3\u00a0during the recovery period after EHDP\u00a0administration significantly improved the uptake of 5Ca by the epiphyseal plate\u00a0while reducing the plate width.<\/p><\/blockquote>\n

and probably also in calves ( Woddard 1997<\/a> ) although that study also included vitamin A.<\/p>\n

This study showed that vitamin A induced growth-plate closure if calves were given an intramuscular injection of vitamins A and D (2,000,000 IU and 300,000 IU, respectively) on the first day after birth<\/p><\/blockquote>\n

So we need to\u00a0ask first\u00a0if an adolescent gets additional\u00a0vitamin A for acne treatment<\/a>.\u00a0For vitamin D supplementation, the case is rather\u00a0unlikely at the moment..\u00a0The only intervention study that I know of\u00a0(<\/span>Morandi 2014<\/a>) missed some important aspects by focusing only on “growing pain”. \u00a0As we now have the possibility of doing PET scans of the epiphysis, it would be a good research question to be safe with vitamin Du supplementation of adolescents.\u00a0<\/span><\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 20.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Having been asked this question, I was only aware of the fact that premature epiphysis closure\u00a0is\u00a0a side effect of isotretinoin therapy in children (Tran 2008). While DELAYED\u00a0epiphysis closure is known for rickets, it is an interesting question if vitamin D supplements given to adolescents will be leading to a premature end of longitudinal growth.\u00a0Maybe this … Continue reading Premature epiphysis closure by high vitamin D supplementation?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-7275","post","type-post","status-publish","format-standard","hentry","category-computer-software"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=7275"}],"version-history":[{"count":11,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7275\/revisions"}],"predecessor-version":[{"id":7286,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7275\/revisions\/7286"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=7275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=7275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=7275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}