{"id":7518,"date":"2015-03-13T12:23:57","date_gmt":"2015-03-13T11:23:57","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=7518"},"modified":"2015-04-01T18:42:33","modified_gmt":"2015-04-01T17:42:33","slug":"u-shape-is-good-and-bad","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2015\/03\/u-shape-is-good-and-bad\/","title":{"rendered":"U shape is good and bad"},"content":{"rendered":"<p>I did not expect that serum vitamin D levels are associated with mortality at both ends of the distribution as now shown by <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=25710567\">Dorup et al.<\/a><\/p>\n<blockquote><p>Out of 247,574 a total of 16.645 subjects died in the ensuing 0 -7 years. &#8230; 25-hydroxyvitamin D level of 70 nmol\/L was associated with the lowest cardiovascular disease mortality risk &#8230; At the higher extreme (\u0002125 nmol\/L), the hazard ratio of cardiovascular disease mortality was 1.3 (95% CI 1.2-1.4), with similar risk among men and women.<\/p><\/blockquote>\n<p>Following our <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19154546\">first paper on U shaped vitamin D effects<\/a> there are now many\u00a0more papers\u00a0show that effect. Vitamin D is not just good or bad, it is both depending on timing, dose, application, whatever.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/03\/U.jpg\" data-rel=\"key-image-0\" data-rl_title=\"\" data-rl_caption=\"\" title=\"\"><img loading=\"lazy\" decoding=\"async\" class=\" size-large wp-image-7519 alignnone\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/03\/U-351x500.jpg\" alt=\"U\" width=\"351\" height=\"500\" srcset=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/03\/U-351x500.jpg 351w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/03\/U.jpg 550w\" sizes=\"auto, (max-width: 351px) 100vw, 351px\" \/><\/a><\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 13.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>I did not expect that serum vitamin D levels are associated with mortality at both ends of the distribution as now shown by Dorup et al. Out of 247,574 a total of 16.645 subjects died in the ensuing 0 -7 years. &#8230; 25-hydroxyvitamin D level of 70 nmol\/L was associated with the lowest cardiovascular disease &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2015\/03\/u-shape-is-good-and-bad\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">U shape is good and bad<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[],"class_list":["post-7518","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=7518"}],"version-history":[{"count":6,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7518\/revisions"}],"predecessor-version":[{"id":7559,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7518\/revisions\/7559"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=7518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=7518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=7518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}