{"id":7743,"date":"2015-08-25T14:31:55","date_gmt":"2015-08-25T13:31:55","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=7743"},"modified":"2015-08-25T14:36:56","modified_gmt":"2015-08-25T13:36:56","slug":"a-step-forward-in-allergy-research","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2015\/08\/a-step-forward-in-allergy-research\/","title":{"rendered":"A  step forward in allergy research"},"content":{"rendered":"<p>The most recent paper of my Australian collaborators is a relevant step forward: <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26260969\">Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy<\/a>. Basically they show an<\/p>\n<blockquote><p>&#8230; association between serum 25-hydroxyvitamin D3 (25[OH]D3) levels and food allergy at age 1 year (338 challenge-proven food-allergic and 269 control participants) and age 2 years (55 participants with persistent and 50 participants with resolved food allergy)&#8230;\u00a0Analyses were stratified by genotype at rs7041 as a proxy marker of DBP levels&#8230; Low serum 25(OH)D3 level (&lt;50 nM\/L) at age 1 years was associated with food allergy, particularly among infants with the GG genotype (odds ratio [OR], 6.0; 95% CI, 0.9-38.9) &#8230;\u00a0Maternal antenatal vitamin D supplementation was associated with less food allergy, particularly in infants with the GT\/TT genotype (OR, 0.10; 95% CI, 0.03-0.41)&#8230; This increases the biological plausibility of a role for vitamin D in the development of food allergy.<\/p><\/blockquote>\n<p>Maybe it would be helpful to have also &#8220;real&#8221; DBP levels for estimating bioavailability (and even data of supplement use) but already the reported\u00a0results are\u00a0another strong argument for the vitamin D &#8211; allergy axis. This is also largely in line with what I predicted back in <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22517291\">2012<\/a><\/p>\n<blockquote><p>Both vitamin D insufficiency and vitamin D supplementation have been linked to allergy and asthma. This apparent paradox is explained by epigenetic programming in pregnancy by low vitamin D levels and the excessive high supplementation in the newborn period.<\/p><\/blockquote>\n<p>Maybe I should have emphasized that genetic variants in the vitamin D pathway are also important for biological effects.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 26.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>The most recent paper of my Australian collaborators is a relevant step forward: Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy. Basically they show an &#8230; association between serum 25-hydroxyvitamin D3 (25[OH]D3) levels and food allergy at age 1 year (338 challenge-proven food-allergic and 269 control participants) &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2015\/08\/a-step-forward-in-allergy-research\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">A  step forward in allergy research<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[199,1287],"class_list":["post-7743","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin","tag-allergy","tag-vitamin-d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7743","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=7743"}],"version-history":[{"count":3,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7743\/revisions"}],"predecessor-version":[{"id":7746,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7743\/revisions\/7746"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=7743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=7743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=7743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}