{"id":785,"date":"2007-03-24T09:44:03","date_gmt":"2007-03-24T08:44:03","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/03\/24\/the-epigenetic-landscape\/"},"modified":"2007-03-26T16:19:38","modified_gmt":"2007-03-26T15:19:38","slug":"the-epigenetic-landscape","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/03\/the-epigenetic-landscape\/","title":{"rendered":"The epigenetic landscape"},"content":{"rendered":"<p>What I always feared, but couldn&#8217;t believe, is now confirmed by renowned experts in a new <a href=\"http:\/\/www.cell.com\/content\/article\/fulltext?uid=PIIS0092867407001869\">Cell<\/a> editorial<\/p>\n<blockquote><p>\nHistorically, the  word &#8220;epigenetics&#8221; was used to describe events that could not be explained by genetic principles.\n<\/p><\/blockquote>\n<p>It goes back to Conrad Waddington &#8211; and describes now such bizarre and inexplicable features like paramutation in maize, position effetc variegation in Drosophila and methylation in humans. There is a nice analogy of the classical 1957 epigenetic landscape figure of Waddington where the course of the ball is influenced by hillls and valleys where it finally arrives &#8211; the <a href=\"http:\/\/www.ipdb.org\/machine.cgi?id=20\">Pinball<\/a> arcade game<\/p>\n<blockquote><p>\nknown factors that may regulate epigenetic phenomena are shown direcing the complex movements of pinballs (cells) across the elegant landscape &#8230; no specific order of molecular events is implied; as such a sequence remains unknown. Effector proteins recognize specific histone modifications&#8230;\n<\/p><\/blockquote>\n<p>[MEDIA=19]<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>What I always feared, but couldn&#8217;t believe, is now confirmed by renowned experts in a new Cell editorial Historically, the word &#8220;epigenetics&#8221; was used to describe events that could not be explained by genetic principles. It goes back to Conrad Waddington &#8211; and describes now such bizarre and inexplicable features like paramutation in maize, position &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/03\/the-epigenetic-landscape\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">The epigenetic landscape<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,5],"tags":[2945,13,2946,834,836,555,284,835],"class_list":["post-785","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","category-philosophy-of-science","tag-genetics-biology","tag-history-insights","tag-philosophy-of-science","tag-epigenetic_phenomena","tag-genetic_principles","tag-histone_modifications","tag-methylation","tag-pinball_arcade"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=785"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/785\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}