{"id":7983,"date":"2015-12-30T12:28:14","date_gmt":"2015-12-30T12:28:14","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=7983"},"modified":"2019-12-03T05:56:18","modified_gmt":"2019-12-03T05:56:18","slug":"ceterum-censeo-i","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2015\/12\/ceterum-censeo-i\/","title":{"rendered":"Ceterum censeo I"},"content":{"rendered":"<p>Are there any\u00a0news in the allergy &amp; vitamin D controversy?<\/p>\n<p>Unfortunately there are still no results from <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1551714414000263\">VDAART<\/a> study on early vitamin D effects &#8211; even after so many years (and expenses of \u00a0&gt;10M $).<!--more--><\/p>\n<p>According to <a href=\"http:\/\/000045362060826\">grantome<\/a>\u00a0VDAART started\u00a0back in 2007 and ended in 2014 (the clinicaltrials.gov listing of 2009-2019 seems\u00a0to be wrong). \u00a0The VDAART trial report at least was reported &#8220;to be under review&#8221; according to \u00a0the\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213260015004245\">Resp Lancet from Dec 2015<\/a>.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-7985\" src=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/12\/sc-620x354.jpg\" alt=\"sc\" width=\"620\" height=\"354\" srcset=\"https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/12\/sc-620x354.jpg 620w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/12\/sc-768x439.jpg 768w, https:\/\/www.wjst.de\/blog\/wp-content\/uploads\/2015\/12\/sc.jpg 830w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><\/p>\n<p>Anyway there is a new report from\u00a0a <a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0145303\">British trial<\/a>\u00a0by Griffiths et al. as published on Dec, 23:<\/p>\n<blockquote><p>In an ethnically stratified randomised controlled trial conducted at St Mary&#8217;s Hospital London, 180 women at 27 weeks gestation were allocated to no Vitamin D, 800 IU ergocalciferol daily until delivery, or a single oral bolus of 200,000 IU cholecalciferol.<\/p><\/blockquote>\n<p>Table 8\u00a0shows a\u00a03 &#8211; 4 fold significantly increased risk for asthma and eczema (medication) during the first 3 years following supplementation during pregnancy. \u00a0Unfortunately, the authors do not\u00a0report\u00a0this result\u00a0in\u00a0the abstract \u00a0&#8211;\u00a0&#8220;what is not allowed cannot happen&#8221;&#8230;<\/p>\n<p>There is also a new Australian trial\u00a0underway (<a href=\"http:\/\/bmjopen.bmj.com\/content\/5\/12\/e009377.full\">VITALITY<\/a>\u00a0&#8211;\u00a0other early intervention studies are <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01498965?term=vitamin+D+allergy&amp;rank=6\">CORK<\/a>, <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00856947?term=vitamin+D+allergy&amp;rank=8\">ABCVitaminD<\/a>\u00a0and\u00a0<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01723852?term=vitamin+D+allergy&amp;rank=16\">VIDI <\/a>totalling\u00a0to 5 ongoing RCTs).<\/p>\n<p>The VITALITY study protocol reads very much like a\u00a0protocol that I have submitted to the BMBF some 7 years ago. There is only one major difference: I wanted to show the risks of vitamin D supplementation while\u00a0<a href=\"http:\/\/www.soziale-paediatrie.med.uni-muenchen.de\/personen\/professoren\/von_kries\/index.html\">funding had been\u00a0declined<\/a> for being &#8220;unethical&#8221; research.<\/p>\n<p>In contrast, the VITALITY\u00a0authors believe that supplementation will reduce the risk of allergic disease and are therefore\u00a0in\u00a0a much better condition to get a study funded. In the end, however, only results will count. It may even be a benefit if you don&#8217;t know so much. Of course there are clinical trials like <a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PII0140-6736(93)90976-N\/abstract\">Guy des Montis 1993<\/a> or <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12207\/abstract;jsessionid=D2335B1C98A9821E430B2E8368497E82.f04t04\">Norizoe 2014<\/a>\u00a0that show a risk of allergic sensitization by vitamin D.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 17.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Are there any\u00a0news in the allergy &amp; vitamin D controversy? Unfortunately there are still no results from VDAART study on early vitamin D effects &#8211; even after so many years (and expenses of \u00a0&gt;10M $). &nbsp; CC-BY-NC Science Surf , accessed 17.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10],"tags":[2554,1861,1755],"class_list":["post-7983","post","type-post","status-publish","format-standard","hentry","category-sunshine-vitamin","tag-rct","tag-clinical-trial","tag-vitamin-d3"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=7983"}],"version-history":[{"count":6,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7983\/revisions"}],"predecessor-version":[{"id":13783,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/7983\/revisions\/13783"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=7983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=7983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=7983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}