{"id":8375,"date":"2016-09-16T11:50:09","date_gmt":"2016-09-16T10:50:09","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=8375"},"modified":"2016-09-19T10:57:13","modified_gmt":"2016-09-19T09:57:13","slug":"forget-the-hygiene-hypothesis-until-there-is-a-good-study","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2016\/09\/forget-the-hygiene-hypothesis-until-there-is-a-good-study\/","title":{"rendered":"Forget the hygiene hypothesis until there is a good study"},"content":{"rendered":"

A new paper in PLoS Negl Trop Dis<\/a> this week\u00a0reports<\/p>\n

The hygiene hypothesis is accepted by many in the global scientific community […] However, aspects of this hypothesis are based on assumptions that may not fully account for realities about human helminth infections. Such realities include evidence of causal associations between helminth infections and asthma or inflammatory bowel disease<\/p><\/blockquote>\n

Talking about realities may help proponents of the hygiene hypothesis who are stuck in a never ending loop publishing \u00a0observational\u00a0studies.<\/p>\n

Even the NEJM\u00a0contributes to the\u00a0hygiene hysteria hype this week<\/a>. Although the allergic rhinitis prevalence isn’t so much lower<\/a> in old order Amish (who are even a heterogenous group), the difference to Hutterite is being highlighted.\u00a0I do not even understand the study design here as it is neither cross-sectional, nor\u00a0case-control nor cohort study. Is it just\u00a0an exposure description in two different groups? \u00a0Conclusions like<\/p>\n

sustained microbial exposure was also reflected in the phenotypes of peripheral innate immune cells in the Amish.<\/p><\/blockquote>\n

are strange\u00a0if we believe that we\u00a0humans carry more bacterial than human cells<\/a>.\u00a0And\u00a0every smoker <\/a>encounters\u00a0a 120fold endotoxin concentration compared to ambient air – without getting rid of asthma or allergy.<\/p>\n

The results of our studies in humans and mice indicate that the Amish environment provides protection against asthma<\/p><\/blockquote>\n

is certainly wrong – nobody knows if this is an environmental or genetic or iatrogenic factor.\u00a0The key finding is IRF7 expression but unfortunately IRF7 plays a critical role in the innate immune response against viruses – and\u00a0not bacteria\/endotoxin…<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

A new paper in PLoS Negl Trop Dis this week\u00a0reports The hygiene hypothesis is accepted by many in the global scientific community […] However, aspects of this hypothesis are based on assumptions that may not fully account for realities about human helminth infections. Such realities include evidence of causal associations between helminth infections and asthma … Continue reading Forget the hygiene hypothesis until there is a good study<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[2018],"class_list":["post-8375","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","tag-hygiene-hypothesis"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=8375"}],"version-history":[{"count":15,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8375\/revisions"}],"predecessor-version":[{"id":8390,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8375\/revisions\/8390"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=8375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=8375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=8375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}