{"id":8843,"date":"2017-01-19T13:45:21","date_gmt":"2017-01-19T12:45:21","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=8843"},"modified":"2022-02-14T07:53:26","modified_gmt":"2022-02-14T05:53:26","slug":"whats-wrong-with-the-hutterities-and-amish-in-the-nejm-paper","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2017\/01\/whats-wrong-with-the-hutterities-and-amish-in-the-nejm-paper\/","title":{"rendered":"Whats’ wrong with the Hutterities and Amish in the NEJM paper?"},"content":{"rendered":"

Following a recent discussion, I looked into more details of the Stein et al. 2016 NEJM paper<\/a>. It claims that<\/p>\n

Despite the similar genetic ancestries and lifestyles of Amish and Hutterite children, the prevalence of asthma and allergic sensitization was 4 and 6 times as low in the Amish.<\/p><\/blockquote>\n

The first sentence is correct. There is a similar genetic ancestry. Although that doesn’t mean anything as overlapping principal component plots are derived only by frequent SNP alleles that have no major disease impact.<\/p>\n

\"\"<\/a><\/p>\n

The second sentence is also correct – and\u00a0known for years\u00a0BUT\u00a0the implicit connection (“despite”) of both sentences is wrong. Propositional calculus<\/a>.<\/p>\n

If we go back to a widely cited paper on population genetics<\/a> it’s clear, that there is big genetic difference between Amish and Hutterities. They have all kind of different disease.<\/p>\n

\"\"<\/a><\/p>\n

We could now safely add also asthma here which means that the paper of Stein et al. is has a wrong conclusion.<\/p>\n

What about the reported mouse model of “experimental allergic asthma”? I wish such a model would exist.\u00a0 I wish there is\u00a0 such a magic dust mix. \u00a0And I wish, there would be reviewers who would have noticed that.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 05.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

Following a recent discussion, I looked into more details of the Stein et al. 2016 NEJM paper. It claims that Despite the similar genetic ancestries and lifestyles of Amish and Hutterite children, the prevalence of asthma and allergic sensitization was 4 and 6 times as low in the Amish. The first sentence is correct. There … Continue reading Whats’ wrong with the Hutterities and Amish in the NEJM paper?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2],"tags":[],"class_list":["post-8843","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=8843"}],"version-history":[{"count":9,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8843\/revisions"}],"predecessor-version":[{"id":19324,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8843\/revisions\/19324"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=8843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=8843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=8843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}