{"id":8879,"date":"2017-03-13T16:29:57","date_gmt":"2017-03-13T15:29:57","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=8879"},"modified":"2019-11-01T07:04:32","modified_gmt":"2019-11-01T07:04:32","slug":"safety-conditions-for-genome-editing","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2017\/03\/safety-conditions-for-genome-editing\/","title":{"rendered":"Safety conditions for genome editing"},"content":{"rendered":"

I would like to see two points added to current CRISPR\/Cas9 guidelines<\/a>.<\/p>\n

First of all, the current gene therapies are not being entered into the clinical trial databases on a regular basis. Maybe as the number of treated patients go down to a single individual or as there is no control group. I would really like the recommendation of a priori entry into clinicaltrials.gov or clinicaltrialsregister.eu (or some newly designed gene therapy databases). Just to get towards a clear risk\/ benefit ratio.<\/p>\n

Second, there should be some way to recognize gene editing. Some\u00a0barcode as we used it already long ago, an\u00a0artificial sequence that indicates the new insert.\u00a0epigenie.com<\/a> summarized the current approaches\u00a0by last summer: Gestalt\/Jay Shendure, barcode\/Stephen R. Quake, scartrace\/Jan Philipp Junker, hgRNA\/Prasant Mali, mScribe\/Tim Lu. Something like the\u00a0FLAG-tag<\/a>. Or more recently<\/a><\/p>\n

R. Kalhor et al., \u201cRapidly evolving homing CRISPRbarcodes,\u201d Nature Methods, doi:10.1038\/nmeth.4108, 2016.
\nS.D. Perli et al., \u201cContinuous genetic recording with self-targeting CRISPR-Cas in human cells,\u201d Science, doi: 10.1126\/science.aag0511, 2016.<\/p><\/blockquote>\n

 <\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 12.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

I would like to see two points added to current CRISPR\/Cas9 guidelines. First of all, the current gene therapies are not being entered into the clinical trial databases on a regular basis. Maybe as the number of treated patients go down to a single individual or as there is no control group. I would really … Continue reading Safety conditions for genome editing<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,9],"tags":[3079],"class_list":["post-8879","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","category-computer-software","tag-genome-editing"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=8879"}],"version-history":[{"count":2,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8879\/revisions"}],"predecessor-version":[{"id":13996,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/8879\/revisions\/13996"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=8879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=8879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=8879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}