{"id":900,"date":"2007-04-14T09:01:00","date_gmt":"2007-04-14T08:01:00","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/04\/14\/when-are-we-being-sensitized\/"},"modified":"2007-04-14T09:01:00","modified_gmt":"2007-04-14T08:01:00","slug":"when-are-we-being-sensitized","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/04\/when-are-we-being-sensitized\/","title":{"rendered":"When are we being sensitized?"},"content":{"rendered":"

JACI<\/a> has a paper in press that addresses this important question. The background is that allergen induced T-cell reactivitiy has been shown in cord blood – a strong argument that sensitization occurs transplacentally. Genotyping of these cells confirmed their fetal origin. It is unclear, however, if this is only a transient (normal?) reaction – and mothers want to know if they need to avoid for example peanuts during pregnancy. Rowe et al. now arrive at a clear conclusion<\/p>\n

\nThese findings question the scientific basis for existing recommendations for allergen avoidance by high-risk women during pregnancy\n<\/p><\/blockquote>\n

Lets have a look at their key result – figure 2B top right:
\np1010106.JPG<\/a><\/p>\n

Only when redrawing their results, I found that the cord blood values are missing from the plot – which certainly weakens their findings. Furthermore we can see 2 individuals (marked with “A” and “B”) that had elevated HDM IgE levels at 6 months and continued to have high values. So, I would slightly modify their conclusions to <\/p>\n

\nAllergen sensitization of the embryo is not the rule but may occur\n<\/p><\/blockquote>\n

If you want to follow this fascinating field here are two links: Prof. Holt’s group<\/a> & a new immune tolerance study<\/a><\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 06.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

JACI has a paper in press that addresses this important question. The background is that allergen induced T-cell reactivitiy has been shown in cord blood – a strong argument that sensitization occurs transplacentally. Genotyping of these cells confirmed their fetal origin. It is unclear, however, if this is only a transient (normal?) reaction – and … Continue reading When are we being sensitized?<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-900","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=900"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/900\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=900"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}