{"id":912,"date":"2007-04-17T18:48:46","date_gmt":"2007-04-17T17:48:46","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/04\/17\/finding-nemo\/"},"modified":"2007-04-17T18:49:30","modified_gmt":"2007-04-17T17:49:30","slug":"finding-nemo","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/04\/finding-nemo\/","title":{"rendered":"Finding Nemo"},"content":{"rendered":"<p><a href=\"http:\/\/www.nature.com\/ng\/journal\/vaop\/ncurrent\/abs\/ng2032.html\">ATG16L1<\/a> is now <a href=\"https:\/\/www.wjst.de\/blog\/2007\/01\/09\/autophagy\/\">confirmed<\/a> as a candidate gene for Crohns disease:<\/p>\n<blockquote><p>\nSpecifically, the LD structure and association mapping around the most associated SNP [&#8230;] rs2241880 implicated a region on chromosome 2q37.1 containing a single gene known as ATG16 autophagy\u00e2\u20ac\u201crelated 16-like 1 (ATG16L1) [&#8230;] Logistic regression analyses conditional on A197T in the family-based samples indicated that this coding variant can fully explain the association signal to this locus; thus, we consider this to be the causal risk variant.\n<\/p><\/blockquote>\n<p>Excellent to have this replication, although the argument above cannot convince me that this already a causal variant.<br \/>\nATG16L1 seems to be most abundant in CD4+ and CD8+ cells and knockdown of the gene will lead to loss of S. typhimurium autophagy. Does rs2241880 really induce a loss of function and how does it relate to TLR7 and NOD2\/CARD15 signalling?<br \/>\nThe authors of another <a href=\"http:\/\/www.nature.com\/nature\/journal\/v446\/n7135\/abs\/nature05698.html\">Nature<\/a> paper believe that there is a primary NF-kB signalling defect in the Toll-like receptor activation by intestinal bacteria &#8211; see also <a href=\"http:\/\/cgap.nci.nih.gov\/Pathways\/Kegg\/hsa04620\">KEGG<\/a> pathways.<br \/>\nIt will be much easier now to ask the right questions.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 09.05.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>ATG16L1 is now confirmed as a candidate gene for Crohns disease: Specifically, the LD structure and association mapping around the most associated SNP [&#8230;] rs2241880 implicated a region on chromosome 2q37.1 containing a single gene known as ATG16 autophagy\u00e2\u20ac\u201crelated 16-like 1 (ATG16L1) [&#8230;] Logistic regression analyses conditional on A197T in the family-based samples indicated that &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/04\/finding-nemo\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Finding Nemo<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-912","post","type-post","status-publish","format-standard","hentry","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=912"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/912\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}