{"id":917,"date":"2007-04-22T09:13:44","date_gmt":"2007-04-22T07:13:44","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/04\/22\/393-mutations-mb\/"},"modified":"2025-06-30T17:06:36","modified_gmt":"2025-06-30T15:06:36","slug":"393-mutations-mb","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/04\/393-mutations-mb\/","title":{"rendered":"3,93 mutations \/ Mb"},"content":{"rendered":"

1 MB is 1 Megabyte is 1,000,000 bytes and 1 Mb is 1 Megabase is 1,000,000 nucleotides. Although a new nature paper<\/a> doesn’t make any fuss about it, there are 3,93 mutations \/ Mb in cancer tissues (in total they found 1,007 mutations by scanning 274 Mb from 210 cancer tissues).
\nThere are some minor inconsistencies as according to the methods they sequenced ~500 bp of ~10,000 fragments from 210 cancers (which would multiply to 1,050 Mb and not 274 Mb) as well as 1,007 \/ 274 is 3,68 (and not 3,93).
\nAnyway, 3,93 \/ Mb is an excessive high figure. If we multiply 3,93 with the 3,100 Mb of the human genome, each cancer cell will have 12,183 acquired somatic mutations which is about 10-fold to conventional wisdom<\/a>.
\nBy looking at the ratio of non-synonymous:synonymous base exchanges, the authors believe that 83% are passenger mutations – this would mean that a “normal” cell of a 70 year old would have acquired 10,092 mutations.<\/p>\n

 <\/p>\n

1\/8\/2007<\/strong><\/p>\n

More estimates in a July 2007 review<\/a>.<\/p>\n

 <\/p>\n

30\/6\/2025<\/strong><\/p>\n

Another update<\/a><\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 05.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

1 MB is 1 Megabyte is 1,000,000 bytes and 1 Mb is 1 Megabase is 1,000,000 nucleotides. Although a new nature paper doesn’t make any fuss about it, there are 3,93 mutations \/ Mb in cancer tissues (in total they found 1,007 mutations by scanning 274 Mb from 210 cancer tissues).   CC-BY-NC Science Surf … Continue reading 3,93 mutations \/ Mb<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[967,966,965,964,963,962,29,961],"class_list":["post-917","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-1_megabyte","tag-acquired","tag-cancer_tissues","tag-conventional_wisdom","tag-fragments","tag-human_genome","tag-mutation","tag-sequencing"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=917"}],"version-history":[{"count":5,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/917\/revisions"}],"predecessor-version":[{"id":25367,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/917\/revisions\/25367"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}