{"id":93,"date":"2006-08-16T15:14:57","date_gmt":"2006-08-16T13:14:57","guid":{"rendered":"http:\/\/146.107.134.84\/wordpress\/index.php\/2006\/08\/16\/the-sib-similiarity-problem\/"},"modified":"2006-08-16T21:40:17","modified_gmt":"2006-08-16T19:40:17","slug":"the-sib-similiarity-problem","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/08\/the-sib-similiarity-problem\/","title":{"rendered":"The sib similiarity problem"},"content":{"rendered":"<p>We have done affected sib pair studies for many years with moderate success as we already described <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=pubmed&#038;cmd=Retrieve&#038;dopt=AbstractPlus&#038;list_uids=11565063&#038;query_hl=20&#038;itool=pubmed_docsum\">five years ago<\/a>. Professor John Edwards brought to my attention the &#8220;<a href=\"http:\/\/www.blackwell-synergy.com\/doi\/abs\/10.1034\/j.1399-0004.2003.630101.x\">sib similiarity problem<\/a>&#8220;, that is still not widely known. ASP  studies are based on &#8220;the premise that a set of  ASPs will share more than the expected proportion of alleles at a disease-susceptibility locus with the implication that these were the sole cause for excess sharing&#8221;. This is not necessarily true and may be one reason of the failure of ASP studies. More or less by chance, I found that that the <a href=\"http:\/\/www.biomedcentral.com\/1471-2156\/6\/2\">observation of 1 discordant sib<\/a> in ASP families be an extremely powerful. &#8220;Being sane in an insane world&#8221; e.g. being healthy while having most of the risk alleles and all the environment risk that made the sibs ill. Yea, yea.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 15.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>We have done affected sib pair studies for many years with moderate success as we already described five years ago. Professor John Edwards brought to my attention the &#8220;sib similiarity problem&#8220;, that is still not widely known. ASP studies are based on &#8220;the premise that a set of ASPs will share more than the expected &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2006\/08\/the-sib-similiarity-problem\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">The sib similiarity problem<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[2945],"class_list":["post-93","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","tag-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/93","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=93"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/93\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=93"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=93"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}