{"id":9404,"date":"2018-01-29T15:56:30","date_gmt":"2018-01-29T14:56:30","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=9404"},"modified":"2018-01-30T07:33:39","modified_gmt":"2018-01-30T06:33:39","slug":"genetics-of-vitamin-d","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/01\/genetics-of-vitamin-d\/","title":{"rendered":"Genetics of vitamin D"},"content":{"rendered":"

A new GWAS of vitamin D<\/a> serum level reports two new loci as sample size could be increased from 16K to 79K. While the previous GWAS hits had a reasonable biological function (GC transport protein, \u00a0DHCR7 converting\u00a0to cholesterol, CYP2R1 \u00a0to calcidiol and CYP24A1 degradation) \u00a0the new loci look more like statistical artifacts.
\nThe authors tried some kind of dose effect estimates<\/p>\n

\"\"<\/a><\/p>\n

where SNP effects on serum level became slightly weaker (which makes sense as diet is a clear environmental factor).<\/p>\n

Unfortunately \u00a0there are no statistical model that look into seasonal effect, although this is being the most important factor in vitamin D epidemiology. The authors correctly describe in their discussion that a<\/p>\n

study conducted by Karohl et al. with 310 monozygotic and 200 dizygotic male twins observed a heritability of 70% during winter, whereas in summer, serum 25-hydroxyvitamin D concentrations appeared to be entirely determined by non-genetic factors (heritability: 0%). Comparable estimates were also identified in a slightly larger study conducted by Mills et al. (winter: 90% vs. summer: 56%). Consistent with season dependency, sex differences were also observed (males: 86% vs. females: 17%)1<\/p><\/blockquote>\n

Given these facts I think it is not sufficient to included just month of examination.<\/p>\n

\"\"<\/a><\/p>\n

I know from at least two datasets that were obtained over more than one and a half year, that monthly effects can not be pooled. There was up to 20% variation between same months. This may be particular true this year where the Guardian wrote<\/a> that this winter is one of darkest ever for parts of Europe.<\/p>\n

the previous low of 13 hours, dating back to 1948, could well be beaten, Fr\u00e9d\u00e9ric Decker of M\u00e9t\u00e9o News told La Voix du Nord this week. \u201cThe forecast isn\u2019t looking too great,\u201d he said. \u201cThe weather\u2019s going to stay pretty damp and dull.\u201d Rouen in Normandy had an even more depressing first half of the month, with just 2.5 hours of sunshine compared with a full-month norm of 58.6, M\u00e9t\u00e9o France said, while Paris\u2019s 10 hours were also a far cry from the 62.5 hours the capital usually averages in January.<\/p><\/blockquote>\n

A winter only analysis could therefore shed more light into vitamin D genetics.<\/p>\n\n

 <\/p>\n

\n CC-BY-NC Science Surf , accessed 02.05.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"

A new GWAS of vitamin D serum level reports two new loci as sample size could be increased from 16K to 79K. While the previous GWAS hits had a reasonable biological function (GC transport protein, \u00a0DHCR7 converting\u00a0to cholesterol, CYP2R1 \u00a0to calcidiol and CYP24A1 degradation) \u00a0the new loci look more like statistical artifacts. The authors tried … Continue reading Genetics of vitamin D<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,10],"tags":[],"class_list":["post-9404","post","type-post","status-publish","format-standard","hentry","category-genetics-biology","category-sunshine-vitamin"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=9404"}],"version-history":[{"count":8,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9404\/revisions"}],"predecessor-version":[{"id":9417,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9404\/revisions\/9417"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=9404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=9404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=9404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}