{"id":965,"date":"2007-05-09T18:04:04","date_gmt":"2007-05-09T17:04:04","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/2007\/05\/09\/osteopontin-bridging-air-pollution-and-immunology-of-allergic-inflammation\/"},"modified":"2007-09-21T12:16:05","modified_gmt":"2007-09-21T10:16:05","slug":"osteopontin-bridging-air-pollution-and-immunology-of-allergic-inflammation","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2007\/05\/osteopontin-bridging-air-pollution-and-immunology-of-allergic-inflammation\/","title":{"rendered":"Osteopontin bridging air pollution and immunology of allergic inflammation"},"content":{"rendered":"<p>Ostepopontin (OPN) is a remarkable substance. The many aliases already point towards a multitude of biological functions: SPP1=secreted phosphoprotein 1, BSPI 1=bone sialoprotein-1, CIT, ETA-1, GC110940, nephropontin, osteoprotegerin, uropontin, bone sialoprotein I, early T-lymphocyte activation among others.<!--more--> We identified osteopontin more than 3 years ago as being upregulated in alveolar macrophages of mice exposed to ambient particles (<a href=\"http:\/\/erj.ersjournals.com\/cgi\/content\/full\/28\/2\/275\">scienceblog:doi:10.1183\/09031936.06.00071205:<\/a>). The immunological function with respect to allergy, however, was not so clear. Osteopontin is regulated by vitamin D response element (VDREs) where gene variants may be already associated with allergy (<a href=\"http:\/\/www.blackwell-synergy.com\/doi\/abs\/10.1111\/j.1399-3038.2006.00456.x\">scienceblog:doi:10.1111\/j.1399-3038.2006.00456.x:<\/a>. I tried to figure out if osteopontin is a pro- or antiallergic substance but the literature on this topic was confusing. If being asked in an exam I would have said that osteopontin can activate dendritic cells and induces their differentiation toward a Th1-polarizing phenotype, relying on an earlier Blood paper (<a href=\"http:\/\/bloodjournal.hematologylibrary.org\/cgi\/content\/full\/106\/3\/946\">scienceblog:doi:10.1182\/blood-2004-08-3228:<\/a> Now a Greek paper in nature medicine has the explanation (<a href=\"http:\/\/www.nature.com\/nm\/journal\/v13\/n5\/abs\/nm1580.html\">scienceblog:doi:10.1038\/nm1580:<\/a>) of this conundrum<\/p>\n<blockquote><p>\n&#8230; OPNs, the secreted form of OPN, exerts opposing effects on mouse TH2 effector responses and subsequent allergic airway disease: pro-inflammatory at primary systemic sensitization, and anti-inflammatory during secondary pulmonary antigenic challenge.\n<\/p><\/blockquote>\n<p>So it may be possible, that vitamin D induced high OPN level lead to sensitization at the first allergen contact; while OPN might have positive effects when treating allergy at a later stage.<\/p>\n<h3>Addendum<\/h3>\n<p>21.9.07 more support at <a href=\"http:\/\/www.pnas.org\/cgi\/content\/full\/104\/37\/14777\">PNAS<\/a> and <a href=\"http:\/\/www.nature.com\/nm\/journal\/v13\/n5\/abs\/nm1580.html\">nature medicine<\/a>.<\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 08.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>Ostepopontin (OPN) is a remarkable substance. The many aliases already point towards a multitude of biological functions: SPP1=secreted phosphoprotein 1, BSPI 1=bone sialoprotein-1, CIT, ETA-1, GC110940, nephropontin, osteoprotegerin, uropontin, bone sialoprotein I, early T-lymphocyte activation among others. &nbsp; CC-BY-NC Science Surf , accessed 08.04.2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,10],"tags":[507,1234,1230,203,1231,1233,1229,1232,578],"class_list":["post-965","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy","category-sunshine-vitamin","tag-alveolar_macrophages","tag-ambient_particles","tag-contact","tag-dendritic_cells","tag-effector_responses","tag-lymphocyte_activation","tag-osteopontin","tag-sensitization","tag-vitamin_d"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=965"}],"version-history":[{"count":0,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/965\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=965"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}