{"id":9677,"date":"2018-03-05T15:20:44","date_gmt":"2018-03-05T14:20:44","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=9677"},"modified":"2018-03-08T14:28:08","modified_gmt":"2018-03-08T13:28:08","slug":"eosinophils-in-asthma","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/03\/eosinophils-in-asthma\/","title":{"rendered":"Eosinophils in asthma"},"content":{"rendered":"<p>There is an update of our <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19198610\">eosinophil SNP paper<\/a>\u00a0now in the Lancet with <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213260018300523\">27 new asthma CpG associations.<\/a>\u00a0The authors claim 3 overlaps to Cookson&#8217;s \u00a0<a href=\"https:\/\/www.nature.com\/articles\/nature14125\">36 IgE loci<\/a>\u00a0while I see only cpg0177040,\u00a0maybe there are two more conicidental findings in the supplement? At least\u00a0the paper says<\/p>\n<blockquote><p>eosinophil counts were not significantly different between patients with asthma and controls in our discovery cohorts, suggesting that our results reflect the presence of a different subset or activation state of eosinophils, rather than a change in eosinophil counts per se. Although eosinophils are linked to sub-phenotypes of asthma such as the T helper 2-type subset, our study provides unequivocal data supporting their involvement at the epigenetic level in mild-to-moderate asthma in children.<\/p><\/blockquote>\n<p>maybe, maybe not &#8211; this could be just residual confounding&#8230;<\/p>\n<blockquote><p>Additionally, CpG methylation patterns identified an early-life shift from naive T cell populations towards effector and memory CD8 and natural killer cell subsets, indicating a potentially crucial role for host virus interactions<\/p><\/blockquote>\n<p>maybe, maybe not &#8211; this could be vaccine effects, some other antigens, allergens or\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4226219\/\">vitamin D<\/a><\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 04.05.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>There is an update of our eosinophil SNP paper\u00a0now in the Lancet with 27 new asthma CpG associations.\u00a0The authors claim 3 overlaps to Cookson&#8217;s \u00a036 IgE loci\u00a0while I see only cpg0177040,\u00a0maybe there are two more conicidental findings in the supplement? At least\u00a0the paper says eosinophil counts were not significantly different between patients with asthma and &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/03\/eosinophils-in-asthma\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Eosinophils in asthma<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-9677","post","type-post","status-publish","format-standard","hentry","category-asthma-allergy"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=9677"}],"version-history":[{"count":5,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9677\/revisions"}],"predecessor-version":[{"id":9706,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9677\/revisions\/9706"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=9677"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=9677"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=9677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}