{"id":9795,"date":"2018-03-20T11:57:09","date_gmt":"2018-03-20T10:57:09","guid":{"rendered":"http:\/\/www.wjst.de\/blog\/?p=9795"},"modified":"2018-03-20T11:57:09","modified_gmt":"2018-03-20T10:57:09","slug":"6th-base","status":"publish","type":"post","link":"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/03\/6th-base\/","title":{"rendered":"6th base"},"content":{"rendered":"<p>I could attend a very interesting talk yesterday of Thomas Carell. \u00a0He reported quite \u00a0a lot of interesting findings in particular as I did not watch that field. Cytosines were long known to exist in two functional states: <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3467341\/\">unmethylated or methylated<\/a> at the 5-position of the pyrimidine ring. \u00a0In 2009 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19372391\">two landmark papers<\/a>\u00a0were published showing that these\u00a05mC in CpG dinucleotides are converted to 5-hydroxymethyl-cytosine (hmC) by the action of oxygenases of the TET family. It turned out to be a complex story how &#8211; using artificial nucleotide incoporation and co-localization of citrate cycle enzymes \u00a0&#8211; the NADH+ dependent process of demethylation was discovered until the most <a href=\"https:\/\/www.nature.com\/articles\/nchembio.2531\">recent publication<\/a>\u00a0of the <a href=\"http:\/\/www.carellgroup.de\/news-epigentic\">Carell group<\/a>. With all the probabilty based research back in my mind, it was such a relief to see a logical pathway to discovery.<i><\/i><\/p>\n\n<p>&nbsp;<\/p>\n<div class=\"bottom-note\">\n  <span class=\"mod1\">CC-BY-NC Science Surf , accessed 20.04.2026<\/span>\n <\/div>","protected":false},"excerpt":{"rendered":"<p>I could attend a very interesting talk yesterday of Thomas Carell. \u00a0He reported quite \u00a0a lot of interesting findings in particular as I did not watch that field. Cytosines were long known to exist in two functional states: unmethylated or methylated at the 5-position of the pyrimidine ring. \u00a0In 2009 two landmark papers\u00a0were published showing &hellip; <a href=\"https:\/\/www.wjst.de\/blog\/sciencesurf\/2018\/03\/6th-base\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">6th base<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-9795","post","type-post","status-publish","format-standard","hentry","category-genetics-biology"],"_links":{"self":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/comments?post=9795"}],"version-history":[{"count":1,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9795\/revisions"}],"predecessor-version":[{"id":9796,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/posts\/9795\/revisions\/9796"}],"wp:attachment":[{"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/media?parent=9795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/categories?post=9795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wjst.de\/blog\/wp-json\/wp\/v2\/tags?post=9795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}