In addition to HLA the most prominent type 1 diabetes genes are INS – CTLA4 – PTPN22 – CD25 – IF1H1, the most prominent asthma/allergy genes ADAM33 – DPP10 – IL12 – IL4 – GPR154 – FLG. I canÂ´t see any joint master regulator, however, we know that
- CD25 is the IL2R
- and just learned from an excellent new mouse study that IL2 gene variation impairs regulatory T cell function
- while IL2 variants are associated with allergy
- IL2 is suppressed by vitamin D – known since 1985
Could that be a model to explain the dual involvement of vitamin D in both diseases?