Finally the ß2 receptor

The full crystal structure of the ß2 receptor is now clear after many attempts for its low natural abundance – with the extracellular domain still difficult to resolve (more on the relevance of the mutations depicted in Fig.1 in my recent Lancet editorial). Interesting: the effects of mutations on distant sites by breaking off van der Waals interactions like I135 that disrupt a ionic lock simply by a more loosely packed molecule.