A secosteroid transcriptional activator

A new vitamin D review is more serious about the biology and possible outcomes than some others.

The popular press is talking about vitamin D as “The Sunshine Vitamin”, promoting it as capable of reducing the risk of cancers and autoimmune disease. Yet vitamin D is actually a secosteroid transcriptional activator, at the heart of the innate immunity.

This looks trivial but it isn´t if you look at the NEJM paper cited above.

the unsupplemental metabolic homeostasis is probably in the range 23-60 nmol/l

which is also close to my estimate. What I did not know so far are the risks discussed with obesity and arthritis. Here is a video from the author