Loss of IL33 -/- protects against allergy

A new paper in Nat Comm shows the power of natural human gene knockouts. Maybe the finding is not really novel but it finally proves the candidate genes – the most important asthma/allergy paper in the last 2 years!

IL33, FLG, HLA-DQB1
GSDMB, BTN3A2, CCHCR1

This is even a nice addition to the most recent review of primary atopic disorders although IL33 is only depicted there in Fig 1.