I would be interested to learn more about the rate of non-matching parent-child SNP assays (preferably Affymetrix technology as current Illumina chips do not include low MAF variants).
This could tell us something about the role of de novo somatic mutations: Read more in a recent TIGS paper by Kenneth Weiss. Has anyone checked different tissues of the same individual and looked for mosaics? Or traced the fate of blood transfusions? Or followed up a single individuals over a couple of years?
This idea is also fuelled by a recent Cell paper that shows Stickerâ€™s sarcoma to be transmitted among dogs by licking or biting tumor-affected areas. Yea, yea.