Working in a field where hundreds of papers are published every year and none is ever retracted, I highly appreciate a letter in Science.

…D1 dopamine receptor (D1R)-stimulated intracellular Ca2+ release was attributed to a direct interaction with calcyon … the ability of calcyon and D1Rs to co-immunoprecipitate when co-expressed in cells as reported presumably stems from the association of both proteins with clathrin-coated vesicles…thus, the isolation of the calcyon clone in a Y2H screen with D1Rs appears to have been adventitious…

In my opinion this comment advance science and give the authors a much higher credibility than any further paper. Yea, yea.


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