Maybe it is easier to answer that question if you are a noble winner. The Guardian is reporting two days ago
Leading academic journals are distorting the scientific process and represent a “tyranny” that must be broken, according to a Nobel prize winner who has declared a boycott on the publications…
Randy Schekman, a US biologist who won the Nobel prize in physiology or medicine this year and receives his prize in Stockholm on Tuesday, said his lab would no longer send research papers to the top-tier journals, Nature, Cell and Science.
With the large distribution factor of the internet, I think there is nothing to loose by sending a paper to PLoS or some of the BMC journals. Quality will survive, yea, yea.