Blood pressure seems to have a complicated regulation according to a recent nature medicine editorial
If you ask a physiologist what organs are involved in blood pressure regulation, you will probably be told the kidney, the brain or the blood vessels. The kidney is responsible for handling sodium … The brain integrates afferent signals from peripheral sites such as the kidney … systemic vascular resistance is elevated in almost all adults with hypertension, suggesting that arteriolar vasoconstriction has an important role in this disease.
The editorial accompanies a new mechanistic report how a high-salt diet leads to interstitial hypertonic Na+ accumulation by activation of tonicity-responsive enhancer binding protein (TonEBP) binding the promoter of the gene encoding vascular endothelial growth factor-C (VEGF-C). As far, as good, Continue reading Forget about genes II