Schlagwort-Archive: arrogance

Can’t believe in a TCRA association (at the moment)

Nature genetics published recently an association paper of an of an autism researcher researcher writing here on narcolepsy

Using genome-wide association (GWA) in Caucasians with replication in three ethnic groups, we found association between narcolepsy and polymorphisms in the TRA@ (T-cell receptor alpha) locus, with highest significance at rs1154155 (average allelic odds ratio 1.69, genotypic odds ratios 1.94 and 2.55, P < 10-21, 1,830 cases, 2,164 controls). This is the first documented genetic involvement of the TRA@ locus, encoding the major receptor for HLA-peptide presentation, in any disease.

I am always cautious of these “first ever” claims Can’t believe in a TCRA association (at the moment) weiterlesen