A new study – repeated by many newspapers – claims genes that rescue even in severe Mendelian disorder: cystic fibrosis, Smith-Lemli-Opitz syndrome, familial dysautonomia, epidermolysis bullosa simplex, Pfeiffer syndrome, autoimmune polyendocrinopathy syndrome, acampomelic campomelic dysplasia and atelosteogenesis.
A comprehensive screen of 874 genes in 589,306 genomes led to the identification of 13 adults harboring mutations for 8 severe Mendelian conditions, with no reported clinical manifestation of the indicated disease.
But we know about the reliability of 23andme results
who even mixed up samples in the past.
Searching for genes that makes your resilient to disease is interesting of course but not very new with more examples of cystic fibrosis survivors available. Any new proof by the 23andme study is missing so far as the authors were unable to recontact any of the 13 resilient indiviuduals for whatever reasons.