Category Archives: Allergy

Allergy research – waste of time

A waste of time – said about another field but applies to allergy research as well (when reading the review request of “Allergy” today)

It’s a problem in science in general. Scientists need to be published which means they need to work on things that their peers are extremely familiar with and can recognize an advance in that area. So, that means that they all need to work on the same thing. The thing they work on… there’s nothing to encourage them to work on things that are practically useful so you get just a whole lot of research which is minor advances and stuff that’s been very highly studied and has no significant practical impact.

Eine Insel der Vernunft

 

https://www.blaetter.de/ausgabe/2022/juni

Jens Kersten. Die dritte Revolution. Plädoyer für ein ökologisches Grundgesetz.

Für die notwendige ökologische Transformation unserer Gesellschaft genügt es jedoch nicht, neue ökologische Grundrechte zu schaffen und die Rechte der Natur anzuerkennen. Damit die ökologischen Rechte im politischen Prozess auch aktiv wahrgenommen und effektiv umgesetzt werden, ist es notwendig, auch die zweite Ebene des Grundgesetzes ökologisch auszugestalten – das Staatsorganisationsrecht. Das klingt zwar technisch, ist aber politisch von zentraler Bedeutung. Denn nur wenn das parlamentarische Regierungssystem für ökologische Rechte sensibilisiert ist, werden diese nicht schlicht in den weiten gesetzgeberischen Abwägungsspielräumen „verpuffen“.

Um die ökologische Sensibilität unseres Staatsorganisationsrechts zu erhöhen, muss zunächst die Ökologie als Staatsfundamentalnorm in Art. 20 Abs. 1 GG verankert werden: Die Bundesrepublik Deutschland ist ein demokratischer, sozialer und ökologischer Bundesstaat.[22] Damit gehört die Ökologie zur verfassungsrechtlichen DNA unserer Staatsorganisation, sodass sie die Arbeit der drei demokratischen Gewalten – Legislative, Exekutive und Judikative – bestimmt.

 

Real collaborations

I have taken part in so many collaborations – on institute level, on a national and on EU level. But usually these collaborations are mainly there on getting monies not in getting any real progress.

So I am very much intrigued by a project in a completely different area – sound localization in the brain – that is simply based on common interest. It includes a great description including a video, Python notebook, discussion forum and is open to everybody who wants to contribute. I wish this would have been possible also in allergy research (where not even published data of the consortium are available for reanalysis).

Why recent allergy congresses failed

Maybe allergy societies, journal editors and conference organizers never grasped the idea of unconferences

An academic conference is a traditional platform for researchers and professionals to network and learn about recent developments and trends in a particular academic field. Typically, the organizing committees and sponsors decide the main theme and sub-topics of the conference and select the presenters based on peer-reviewed papers. The selected speakers usually share their research with a large audience by means of presentations and posters. However, the most stimulating discussions generally take place over coffee breaks when attendees can interact with each other and discuss various topics, including their own research interests, in a more informal manner, while expanding their own professional networks. An emphasis on facilitating such informal/networking interactions is a central focus of “unconventional conferences”—or “unconferences.”

https://twitter.com/OdedRechavi/status/1522792505124790272 Continue reading Why recent allergy congresses failed

The Lancet and scientific integrity

We have learned in the past that the Lancet published editorials that clearly separated the journal from the publisher Elsevier

Reed Elsevier’s response is that the sale of military equipment is legal, government supported, and tightly regulated. However, The Lancet‘s collaborations in child survival and health-systems strengthening, for example, risk being tainted by Reed Elsevier’s promotion of the “selling process” of arms.

Of course you can’t sell weapons and distance yourself from selling weapons at the same time…

Die neue S3 Leitlinie Allergieprävention zu Vitamin D

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Hass muss man sich verdienen, Mitleid gibt es geschenkt

Ein sehr schönes Interview im LJ mit Katharina Schüller(Mitautorin der „Unstatistik“), das mit vielen anderen Stimmen [1,2,3,4] mal wieder zeigt, wie schlecht unsere COVID-19 Datenlage in Deutschland ist und dabei auch meine Forderung vom März 2020 nach repräsentativen Daten wiederholt. Was es mit dem Titel auf sich hat? Es ist die Antwort in dem Interview auf die Frage

Macht Ihnen Ihre „Unstatistik“, speziell in Verbindung mit Corona, eigentlich viel Ärger?

Kann Milch vor Allergien schützen?

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What did Sequana really find at Tristan da Cunha?

The Tristan study described before was leading to patent US6087485A. It describes

highly significant linkage in the genome scan (p=0.0001 for history of asthma and p=0.0009 for methacholine challenge) … at D11S907, a marker on the short arm of chromosome 11.

D11S907 or  AFM109YA1 is a microsatellite marker located at 11p13 in a gene known as EHF.  There should be 2 genes in close proximity of the marker: ASTH1I and ASTH1J.

ASTH1I and ASTH1J were detected by exon trapping. ASTH1I exons detected a 2.8 kb mRNA expressed at high levels in trachea and prostate, and at lower levels in lung and kidney …
ASTH1J exons detected a 6.0 kb mRNA expressed at high levels in the trachea, prostate and pancreas and at lower levels in colon, small intestine, lung and stomach.

The sequences of  table 2 in the patent are sufficient now to locate ASTH1I and ASTH1J. Continue reading What did Sequana really find at Tristan da Cunha?

25 years Transatlantic Airway Conference 1997 on asthma genetics in Key Biscayne

The conference series started in 1986 while the 12th conference was organized by Jeff Drazen with local support of Adam Wanner.

Sponsored by Boehringer Ingelheim, the participant list is the WHO is WHO in pulmonary genetics at that time: Bleecker, Meyers, Woolcock, Weiss, Burrows, Postma, Kauffmann, Dizier, LeSouef, Blumenthal, Banks-Schlegel, Slutsky, Zamel, Ober, Bousquet, Vercelli, Barnes, Adcock, Dahlen, Pauwels, Lewitt, Aron, Martinez, Cookson, Moffatt, Rosenwasser, Liggett, Rich, Papadopoulos, Levitt, Holgate, Elston, Morton and Marsh. Many of them do not live any more [1,2,3,4,5], some have made big careers [1,2], others have been fallen somewhat into disgrace [1,2,3]  and many already retired. Continue reading 25 years Transatlantic Airway Conference 1997 on asthma genetics in Key Biscayne