I have predicted an epigenetic regulation of vitamin D converting enzymes in 2010 to explain the programming effect of vitamin D supplements on later allergy.
Last week, a first study examining vitamin D supplement effects in newborns has been published. They compare 400IU versus 3800IU while I am already convinced that 400 IU has some measureable effect.
So maybe I was wrong with my prediction of a differential CYP24A1 methylation, as the authors now describe CYP7B1. CYP7B1 encodes for 25-hydroxycholesterol 7-alpha-hydroxylase which is more upstream in the synthesis of cholesterol.
