Blackley found already in 1873 an interesting explanation of the “no allergy in farming children” effect by referring to some kind of auto desensitization in this particular environment – e.g. the high pollen and LPS exposure.
Do you know that a commercial allergen preparation used for desensitization already includes a LPS derivate, 3-o-desacyl-4′ monophosphoryl lipid A as an adjuvant? It is believed to push the pollen reaction into a IL12 – IFNg – Th1 pathway. This therapeutic approach already perfectly fits the early explanation of Blackley.
When will the allergy farming lobby ultimately close their files?