“Positively disruptive” – a new nature genetics editorial – makes a U turn of the opinion voiced only two months earlier – having at that time cautioned users of new consumer genomics services. The current editorial now reads like an advertisement for deCODEme or Navigenics. Continue reading Unnecessarily disruptive
A recent study published in nature genetics study highlights a ß-defensin gene where increased copy numbers are related to psoriasis. The normal range is 2 – 12 copies with the risk increasing with each extra copy. I donÂ´t know if the given explanation is really correct: more genomic copies lead to more RNA, lead to more antimicrobial peptide, lead to skin inflammation. Maybe there is an unknown intermediate step: more antimicrobial peptide -> induce other inflammtory interleukins -> skin inflammation.
In any case, Continue reading New psoriasis gene would have been missed by testing linkage only