Schlagwort-Archive: cytokines

Contrary or Contradictory

A forthcoming “Perspectives in asthma” paper in “JACI” by Litonjua and Weiss will be about the vitamin D hypothesis. Although the authors find that

Evidence exists that vitamin D induces a shift in the balance between TH1 and TH2-rype cytokines toward TH2 dominance

they make a largely unexpected turn by saying that vitamin DEFICIENCY may be to blame for the asthma epidemic. The basic argumentation is

We hypothesize that as populations grow more prosperous and more Westernized, more time is spent indoors and there is less exposure to sunlight leading to vitamin D deficiency…

Given the immediate and effective vitamin D production in skin and its longterm availability by fat stores I cannot follow their last conclusion. Contrary or Contradictory weiterlesen