A forthcoming “Perspectives in asthma” paper in “JACI” by Litonjua and Weiss will be about the vitamin D hypothesis. Although the authors find that
Evidence exists that vitamin D induces a shift in the balance between TH1 and TH2-rype cytokines toward TH2 dominance
they make a largely unexpected turn by saying that vitamin DEFICIENCY may be to blame for the asthma epidemic. The basic argumentation is
We hypothesize that as populations grow more prosperous and more Westernized, more time is spent indoors and there is less exposure to sunlight leading to vitamin D deficiency…
Given the immediate and effective vitamin D production in skin and its longterm availability by fat stores I cannot follow their last conclusion. Continue reading Contrary or Contradictory
moblog – I have now spent another day at the Berlin Document Center browsing through hundreds of RKI pages – manuscripts, correspondence, bills and personal files. My goal was to find out why the allergy epidemic did not already start off 1935 in Germany when vitamin D synthesis was already possible on a large scale.
Indeed, I found evidence that at least 3 companies radiated at that time yeast derived ergosterin by UV quartz lamps – I.G. Farben, Nordmark-Werke and Deutsche Vitamin Gesellschaft. The number of companies in this field Continue reading Why the allergy epidemic did not already start 1935 in Germany
There is an ongoing discussion if 25-OH-D3 serum values can be used to diagnose vitamin D insufficiency. At least for rickets outcome there are now quantitatitive data that allow a comparison of clinical symptoms, radiological findings, cholecalciferol and alkaline phosphatase levels. I have rearranged the values of a new paper into the following figure Continue reading Dont look at serum values alone