How it is going, how it started – asthma genome wide scans

Here are the most recent GWAS data for asthma – not identical peaks but quite similar

How it is going: 2020-2021

azphewas.com

big.stats.ox.ac.uk

pheweb.sph.umich.edu

r2.finngen.fi

www.ebi.ac.uk

 

How it started: 1996-1998

third linkage scan (my thesis)

second  linkage scan (CSGA)

first linkage scan (Cookson)

 

More than 2 decades ago we found hits on chr 2, 6, 9, 12 (only missing  chr17q21 where our marker coverage wasn’t good enough). Our genome scan was therefore the very first identification of the IL33 region although the gene could be described only 7 years later. Remarkably, that this result was possible with just 415 carefully examined individuals instead of 500,000 individuals nowadays (see also the asthma genetics timeline).